top of page

Research

At P-NAS lab we focus on novel ideas pertaining to the synthesis and use of various nanoparticles in healthcare. We believe in the ideology of multidisciplinary collaborations which enables us to integrate newer approaches. Nanotechnology has shown immense potential in tackling problems of modern medicine in recent times, but yet there remains many unanswered questions .........

Publications

images_large_tz3c00616_0008.jpeg

The Multifaceted Role of Degradable Cobalt Nanoparticles: Dual-Target Starvation and Intracellular Acidification Engendering LC3- Associated Whole-Cell Autophagy
​​Gayathri Ravichandran.....AK Rengan* ACS Materials Letters - 2023

amlcef.2023.5.issue-10.largecover.jpg
Applied materials and interfaces.jpg
Get1_edited_edited.jpg
ACS Sust.jpg
Picture2.jpg
Inter J BioMacro.jpg
Biomacromolecules.png
Biomaterial Science and Engineering.jpg
Photo Chem n Bio.jpg
showCoverImage.jpg

Selected Original Research Articles

  • Sajmina Khatun...............A.K. Rengan*, 7-Amino-6H-anthra[9,1-cd] Isothiazol-6-one-Casein Nanosystem for Live Cell Staining and Augmenting Therapeutic Effectiveness in Triple Negative Breast Cancer, ACS Applied Nano Materials (2024) 

  • Sajmina Khatun...............A.K. Rengan*, Glutathione - IR 797 coupled Casein Nano-Trojan for augmenting the therapeutic efficacy of camptothecin in highly invasive triple-negative breast cancer, Biomaterials Advances (2024) 159

  • Mohammad Sadik Ali..............A.K. Rengan*, Accelerating Diabetic Wound Healing by Modulating the Inflammatory Environment using Quercetin-Rosemary Oil Lipid Nanoemulsions with Artificial Intelligence-based Wound Closure Analysis, Advanced Therapeutics  (2023) 034

  • Gayathri Ravichandran,...............A.K. Rengan*, The Multifaceted Role of Degradable Cobalt Nanoparticles: Dual-Target Starvation and Intracellular Acidification Engendering LC3-Associated Whole-Cell Autophagy, ACS Materials Letters 5 (2023) 2726

  • Sunil Venkanna Pogu, Dokkari Nagalaxmi Yadav, ...............A.K. Rengan* Copper iodide microhexagons: a potential therapeutic agent for surface microbial infection and melanoma Materials Advances 10 (2023) 1039

  • Dokkari Nagalaxmi Yadav, Sri Amruthaa, ...............A.K. Rengan* Bioinspired Gold coated Phage Nanosomes for Anti-Microbial and Anti-CancerTheranostics Materials Today Nano  23 (2023) 100348

  • Sushma Mudigunda, Sri Amruthaa,...........A.K. Rengan*, Ethosomal Nanoformulations for Combinational Photothermal Therapy of Fungal Keratitis Advanced Therapeutics 6 (2023)2200331 

  • S Khatun, M Pebam, CL Putta, A.K. Rengan*,  Camptothecin loaded Casein nanosystem for turning the therapeutic efficacy against highly metastatic triple-negative breast cancer cells, Biomaterials Science,11 (2023) 2518.

  • A Prajapati, A Srivastava, ...............A.K. Rengan*, High-Affinity DNA NAnomatrix: A platform technology for synergistics Drug Delivery and Photothermal Therapy, ACS Macro Letters 12 (2023) 255.

  • SV Mudigunda, DB Pemmaraju, SA Sankaranarayanan, A.K. Rengan*, Bioactive Polymeric Nanoparticles of Moringa oleifera Induced Phyto-Photothermal Sensitization for the Enhanced Therapy of Retinoblastoma, Pharmaceutics 2(2023), 15.

  • Vinod R. Shinde, S. Khatun, Ajinkya M. Thanekar, A. Hak, A.K. Rengan*, Lipid-Coated Red Fluorescent Carbon Dots for Imaging and Synergistic Phototherapy in Breast Cancer, Photodiagnosis and Photodynamic Therapy 41 (2023), 103314.

  • S.B.Alvi, P.S.Rajalakshmi, A.B.Jogdand, B.Nazia, V.Bantal, A.K.Rengan, Chitosan IR806 dye-based polyelectrolyte complex nanoparticles with mitoxantrone combination for effective chemo-photothermal therapy of metastatic triple-negative breast cancer, International Journal of Biological Macromolecules216, (2022),558.

  • Monika Pebam, Rajalakshmi P.S., Madhusree Gangopadhyay, Shashidhar Thatikonda, and Aravind Kumar Rengan*, Terminalia chebula Polyphenol and Near-Infrared Dye-Loaded Poly(lactic acid) Nanoparticles for Imaging and Photothermal Therapy of Cancer Cells , ACS Applied Bio Materials, 11,(2022) 5333.

  • Tejaswini Appidi, PS Rajalakshmi, Shubham A Chinchulkar, Arpan Pradhan, Hajera Begum, Veeresh Bantal, Rohit Srivastava, Ganesan Prabusankar, A.K.Rengan*, Plasmon-enhanced fluorescent gold coated novel lipo-polymeric hybrid nanosystem: Synthesis, characterization and application for imaging and photothermal therapy of breast cancer, Nanoscale 14 (2022) , 9112.

  • V.S.Mudigunda, D.Pemmaraju, S.Paradkar, E.R.Puppala,  B.Gawali, USN Murthy, VGM Naidu, A.K.Rengan*, Multifunctional polymeric nanoparticles for chemo/photo theranostics of retinoblastoma, ACS Biomat.Sci.Engg 8 (2022) 151–160.

  • Gangwar, Rahul, Karri Trinadha Rao, Sajmina Khatun, Aravind Kumar Rengan, Challapalli Subrahmanyam, and Siva Rama Krishna Vanjari. "Label-free miniaturized electrochemical nanobiosensor triaging platform for swift identification of the bacterial type." Analytica Chimica Acta  1233 (2022): 340482 .

  • S.B. Alvi, R. P S, N. Begum, A.B. Jogdand, B. Veeresh, A.K. Rengan*, In Situ Nanotransformable Hydrogel for Chemo-Photothermal Therapy of Localized Tumors and Targeted Therapy of Highly Metastatic Tumors, ACS Appl. Mater. Interfaces. (2021) 13,55862. 

  • Rajalakshmi P.S, S.B. Alvi, N. Begum, B. Veeresh, A.K. Rengan*, Self-Assembled Fluorosome-Polydopamine Complex for Efficient Tumor Targeting and Commingled Photodynamic/Photothermal Therapy of Triple-Negative Breast Cancer, Biomacromolecules. 22 (2021) 3926. 

  • S.B. Alvi, P.S. Rajalakshmi, A. Jogdand, A.Y. Sanjay, B. Veeresh, R. John, A.K. Rengan*, Iontophoresis mediated localized delivery of liposomal gold nanoparticles for photothermal and photodynamic therapy of acne, Biomater. Sci. 9 (2021) 1421.

  • D.V.S.K. Gunapu, Y.B. Prasad, V.S. Mudigunda, P. Yasam, A.K. Rengan, R. Korla, S.R.K. Vanjari, Development of robust, ultra-smooth, flexible and transparent regenerated silk composite films for bio-integrated electronic device applications, Int. J. Biol. Macromol. 176 (2021) 498. 

  • K.K. Gudimella, T. Appidi, H.F. Wu, V. Battula, A. Jogdand, A.K. Rengan*, G. Gedda*, Sand bath assisted green synthesis of carbon dots from citrus fruit peels for free radical scavenging and cell imaging, Colloids Surfaces B Biointerfaces. 197 (2021) 111362. 

  • P. Das, S. V. Mudigunda, G. Darabdhara, P.K. Boruah, S. Ghar, A.K. Rengan*, M.R. Das*, Biocompatible functionalized AuPd bimetallic nanoparticles decorated on reduced graphene oxide sheets for photothermal therapy of targeted cancer cells, J. Photochem. Photobiol. B Biol. 212 (2020) 112028. 

  • A. Thomas, T. Appidi, A.B. Jogdand, S. Ghar, K. Subramaniyam, G. Prabusankar, J.R. Mohanty, A.K. Rengan*, Facile Synthesis of Fluorescent Polymer Encapsulated Metal (PoeM) Nanoparticles for Imaging and Therapeutic Applications, ACS Appl. Polym. Mater. 2 (2020) 1388. 

  • T. Appidi, D.B. Pemmaraju, R.A. Khan, S.B. Alvi, R. Srivastava, M. Pal, N. Khan*, A.K. Rengan*, Light-triggered selective ROS-dependent autophagy by bioactive nanoliposomes for efficient cancer theranostics, Nanoscale. 12(2020) 2028. 

  • A. Jogdand, S.B. Alvi, P.S. Rajalakshmi, A.K. Rengan*, NIR-dye based mucoadhesive nanosystem for photothermal therapy in breast cancer cells, J. Photochem. Photobiol. B Biol. 208 (2020) 111901. 

  • S.B. Alvi, T. Appidi, B.P. Deepak, P.S. Rajalakshmi, G. Minhas, S.P. Singh, A. Begum, V. Bantal, R. Srivastava, N. Khan, A.K. Rengan*, The “nano to micro” transition of hydrophobic curcumin crystals leading to: In situ adjuvant depots for Au-liposome nanoparticle mediated enhanced photothermal therapy, Biomater. Sci. 7 (2019) 3866. 

  • D. Pemmaraju, T. Appidi, G. Minhas, S.P. Singh, N. Khan, M. Pal, R. Srivastava*, A.K. Rengan*, Chlorophyll rich biomolecular fraction of A. cadamba loaded into polymeric nanosystem coupled with Photothermal Therapy: A synergistic approach for cancer theranostics, Int. J. Biol. Macromol. 110 (2018) 383. 

  • A.K. Rengan, A.B. Bukhari, A. Pradhan, R. Malhotra, R. Banerjee, R. Srivastava*, A. De, In Vivo Analysis of Biodegradable Liposome Gold Nanoparticles as Efficient Agents for Photothermal Therapy of Cancer, Nano Lett. 15 (2015) 842.

  • A.K. Rengan, M. Jagtap, A. De, R. Banerjee, R. Srivastava*, Multifunctional gold coated thermo-sensitive liposomes for multimodal imaging and photo-thermal therapy of breast cancer cells, Nanoscale. 6 (2014) 916. 

Nanoletters.jpg
X15721000.jpg
materials today communication.jpg
001aabm.jpeg
Applied Polymer materials.jpg
Picture3.jpg
Materialia.jpg
X00032670.jpg

Review Articles

  • Hima Sree Buddhiraju.........A K Rengan* Advances in Peptide-Decorated Targeted Drug Delivery: Exploring Therapeutic Potential and Nanocarrier Strategies, ACS Applied Bio Materials (2023) 

  • Nitisha Beniwal..........A K Rengan*, Recent Trends in Bio-nanomaterials and Non-invasive Combinatorial Approaches of Photothermal Therapy against Cancer, Nanotheranostics (2024) 8(2)

  • Pavani Chowdary, Ananya Padmakumar, A K Rengan Exploring the potential of transethosomes in therapeutic delivery: A comprehensive review MedComm – Biomaterials and Applications 4 (2023) e59

  • Chandra Lekha Putta .......A. K. Rengan* Melatonin: Avenues in cancer therapy and its nanotechnological advancements MedComm – Biomaterials and Applications 2 (2023) e58

  • Monika Pebam....... A. K. Rengan* Nano Phyto-Phenols as potential immunomodulators: A review  Food and Humanity 1(2023) 809

  • Rounik Karmakar....... A. K. Rengan* Attributes of Nanomaterials and Nanotopographies for Improved Bone Tissue Engineering and Regeneration  ACS Applied Bio Materials (2023) 

  • Ananya Padmakumar, ........, A. K. Rengan* Bacteria-Premised Nanobiopesticides for the Management of Phytopathogens and Pests ACS Agric. Sci. Technol.10(2023)1021

  • Sadik Ali Mohammad, Arshadul Hak,.......A. K. Rengan* Radiotherapy, photodynamic therapy, and cryoablation‐induced abscopal effect: Challenges and future prospects Cancer Innovation 10(2023)1002

  • Sunil Venkanna Pogu, Dheeraj Dehariya,..........A. K. Rengan* A review on fabrication, actuation, and application of magnetic force driven, light-driven and DNA nano/microrobots in modern theranostics Molecular System Design and Engineering  4 (2023) 2546

  • Dheeraj Dehariya, Kalyani Eswar,..............., A. K. Rengan*Recent Advances of Nanobubble-based systems in Cancer Therapeutics: A Review Biomedical Engineering Advances 5 (2023)  100080

  • K Eswar, S Mukherjee, ......, A.K. Rengan*, Immunomodulatory Natural Polysaccharides: An Overview of the Mechanisms Involved - European Polymer Journal, 188 (2023) 111935.

  • S Khatun, CL Putta, A Hak, A. K. Rengan*, Immunomodulatory nanosystems: An emerging strategy to combact viral infections, Biomaterials, and Biosystems, 9 (2023) 100073.

  • A. Hak, M.S. Ali, S.A. Sankarnarayana, Vinod R. Shinde, A. K. Rengan*, Chlorine e6: A Promising Photosensitizer in Photo-Based  Cancer Nanomedicine, ACS Applied Bio Materials 6 (2023) 349.

  • Sajmina Khatun, Tejaswini Appidi,A. K. Rengan* Casein nanoformulations - Potential biomaterials in Food Bioscience (2022)

  • SA Chinchulkar, P Patra, D Dehariya, A Yu, AK Rengan, Polydopamine nanocomposites and their biomedical applications: A review, Polymers for Advanced Technologies, 10. (2022)5863.

  • DN Yadav, MS Ali, AM Thanekar, SV Pogu… A.K.Rengan*, Recent advancements in the design of nanodelivery systems of siRNA for cancer therapy, Mol. Pharmaceutics 19 (2022) 4506.

  • Pratyusha Sambangi, Subramaniam Gopalakrishnan, Monika Pebam , A.K.Rengan* , Nano-biofertilizers on soil health, chemistry, and microbial community: benefits and risks, Proceedings of the Indian National Science Academy volume 88, pages 357–368 (2022)

  • NP Koyande, R Srivastava, A Padmakumar, AK Rengan, Advances in Nanotechnology for Cancer Immunoprevention and Immunotherapy: A Review, Vaccines 10 (2022)1727.

  • P Patra, AK Rengan, Cancer Cell Membrane Cloaked Nanocarriers: A Biomimetic Approach Towards Cancer Theranostics, Materials Today Communications, 10 (2022) ​4289

  • A. Padmakumar, N. P. Koyande, & A. K. Rengan*, Role of hitchhiking on cancer therapeutics, Advanced Therapeutics 12 (2022) 42.

  • N. Koyande, M. Gangopadhyay, S. Thatikonda, A. K. Rengan*, The role of gut microbiota in the development of colorectal cancer: a review, International Journal of Colorectal Disease (2022) 37, 1509.

  • S. Khatun, T. Appidi, A.K. Rengan*, The role played by bacterial infections in the onset and metastasis of cancer, Curr. Res. Microb. Sci. 2 (2021) 100078. 

  • S.P. Singh, T. Appidi, A.K. Rengan*, Biodegradable/disintegrable nanohybrids for photothermal theranostics, Proc. Indian Natl. Sci. Acad. 87 (2021) 94.

  • A. Hak, V. Ravasaheb Shinde, A.K. Rengan*, A review of advanced nanoformulations in phototherapy for cancer therapeutics, Photodiagnosis Photodyn. Ther. 33 (2021) 102205. 

  • A.M. Thanekar, S.A. Sankaranarayanan, A.K. Rengan*, Role of nano-sensitizers in radiation therapy of metastatic tumors, Cancer Treat. Res. Commun. 26 (2021) 100303. 

  • G. Ravichandran, A.K. Rengan*, Aptamer-mediated nanotheranostics for cancer treatment: A review, ACS Appl. Nano Mater. 3 (2020) 9542 

  • G. Darabdhara, M.R. Das*, S.P. Singh, A.K. Rengan*, S. Szunerits, R. Boukherroub, Ag and Au nanoparticles/reduced graphene oxide composite materials: Synthesis and application in diagnostics and therapeutics, Adv. Colloid Interface Sci. 271 (2019) 101991. 

  • P. Yadav, S.P. Singh, A.K. Rengan, A. Shanavas, R. Srivastava*, Gold laced bio-macromolecules for theranostic application, Int. J. Biol. Macromol. 110 (2018) 39.

3-s2.0-C2020002699X-cov200h.gif
9781119617181.cover.gif
978-981-16-2782-8.jfif
Advances in Colloid and interface.jpg
Applied Nanomaterials.jpg
INSA.png
Photo diagnosis and dynamic therapy.jpg
384.jpg
pat.v33.12_edited.jpg
Picture1.tif
1-s2.0-S2666517420X00034-cov200h.jpeg

Book Chapters

  • Rupali Srivastava............A.K. Rengan* (2024), Phytonanotechnologies for Addressing Antimicrobial Resistance, Medicinal Plants and Antimicrobial Therapies Springer

  • Sivasubramanian Murugappan............. A.K. Rengan* (2024), Drug-delivery, Antimicrobial, Anticancerous Applications of Green Synthesized Nanomaterials, Green Synthesis of Nanomaterials: Biological and Environmental Applications Wiley

  • Anindita Tarafdar..........A.K. Rengan* (2023) X-ray photoelectron spectroscopy for biomedical applications Analytical Techniques for Biomedical Nanotechnology  IOP Publishing

  • Aditya Srivastava..........A.K. Rengan* (2023) The Evolution of 3D Graphene and Its Derivatives for Theranostic Applications 3D Graphene Springer

  • Sabeerabi Bonala.......A.K. Rengan* (2023) Nanovectors for theranostic applications Advanced Nanoformulations Academic press

  • Sankaranarayanan SA........A.K. Rengan* (2023) Albumin-based nanocarriers for therapeutic applications Polymeric Nanosystems  Academic press

  • Shubham Arunrao Chinchulkar.......A.K. Rengan* (2023) 22 - Gold nanoparticle-based biosensing applications and fundamentals of sensor technology: principles and novel designs Fundamentals of Sensor Technology Elsevier

  • Shubham A. Chinchulkar, Sankaranarayanan S.A., A.K. Rengan* (2023) Nanobiosensor: Advancement in Disease Diagnostic, Springer.

  • T. Appidi, S. Mudigunda, A.K. Rengan* (2022) Cellulose Nanocrystals, Springer.

  • T. Appidi, S. Mudigunda, A.K. Rengan* (2022) Multi-Organs-on-a-Chip in Disease Modelling, Springer.

  • Sankaranarayanan S.A., Singh S.P., A.K. Rengan*. (2022) Theranostics: Principles, Materials, and Technical Advancements - BioSensing, Theranostics, and Medical Devices, Springer.

  • J.K.Gangasani, D.B.Pemmaraju, USN Murthy, A.K. Rengan, VGM Naidu* (2022) Chemistry of herbal biomolecules: Herbal Biomolecules in Healthcare Applications, Academic Press

  • D.B.Pemmaraju, A.Ghosh, J.K.Gangasani, USN Murthy, VGM Naidu, A.K.Rengan* (2022) Herbal biomolecules as nutraceuticals: Herbal Biomolecules in Healthcare Applications, Academic Press

  • SP Singh, AK Rengan* (2021) Microbial Interactions at Nanobiotechnology Interfaces: Molecular Mechanisms and Applications - Molecular Mechanisms Behind Nano‐Cancer Therapeutics, John Wiley & Sons, Inc.

  • S.P. Singh, A.K. Rengan* (2019) Nanomaterials for Antibiofilm Activity, Introd. to Biofilm Eng. Part 6 - Nanomater. Antibiofilm Act.

 

        * - Corresponding Author

Link to updated research articles

google-scholar-png.png

Funding Agencies

ICMR.jpg
JICA1.jpg
Ukri_Nerc_Logo.jpg
DBT.jpg
MoEdu.jpg
DST1.png
SERB-LOGO.png
inspire1.jpg
imprint-logo.jpg
Vasudha Foundation.png
z - British Council.jpg
newton-bhabha-master-rgb_0.jpg
bottom of page