In Situ Nanotransformable edited_edited_

In Situ Nanotransformable Hydrogel for Chemo-Photothermal Therapy of Localized Tumors and Targeted Therapy of Highly Metastatic Tumors

S. B. Alvi,...., A. K. Rengan*, ACS Appl. Mater. Interfaces 2021, 13, 47, 55862–55878

Research

At P-NAS lab we focus on novel ideas pertaining to the synthesis and use of various nanoparticles in healthcare.We belief in the ideology of multidisciplinary collaborations which enables us to integrate newer approaches. Nanotechnology has shown immense potential in tackling problems of modern medicine in recent times, but yet there remains many unanswered questions .........

Publications

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Selected Original Research Articles

  • V.S.Mudigunda, D.Pemmaraju, S.Paradkar, E.R.Puppala,  B.Gawali, USN Murthy, VGM Naidu, A.K.Rengan*, Multifunctional polymeric nanoparticles for chemo/photo theranostics of retinoblastoma, ACS Biomat.Sci.Engg (2022) - In Press

  • S.B. Alvi, R. P S, N. Begum, A.B. Jogdand, B. Veeresh, A.K. Rengan*, In Situ Nanotransformable Hydrogel for Chemo-Photothermal Therapy of Localized Tumors and Targeted Therapy of Highly Metastatic Tumors, ACS Appl. Mater. Interfaces. (2021) 13, 47, 55862–55878. 

  • Rajalakshmi P.S, S.B. Alvi, N. Begum, B. Veeresh, A.K. Rengan*, Self-Assembled Fluorosome-Polydopamine Complex for Efficient Tumor Targeting and Commingled Photodynamic/Photothermal Therapy of Triple-Negative Breast Cancer, Biomacromolecules. 22 (2021) 3926–3940. 

  • S.B. Alvi, P.S. Rajalakshmi, A. Jogdand, A.Y. Sanjay, B. Veeresh, R. John, A.K. Rengan*, Iontophoresis mediated localized delivery of liposomal gold nanoparticles for photothermal and photodynamic therapy of acne, Biomater. Sci. 9 (2021) 1421–1430.

  • D.V.S.K. Gunapu, Y.B. Prasad, V.S. Mudigunda, P. Yasam, A.K. Rengan, R. Korla, S.R.K. Vanjari, Development of robust, ultra-smooth, flexible and transparent regenerated silk composite films for bio-integrated electronic device applications, Int. J. Biol. Macromol. 176 (2021) 498–509. 

  • K.K. Gudimella, T. Appidi, H.F. Wu, V. Battula, A. Jogdand, A.K. Rengan*, G. Gedda*, Sand bath assisted green synthesis of carbon dots from citrus fruit peels for free radical scavenging and cell imaging, Colloids Surfaces B Biointerfaces. 197 (2021) 111362. 

  • P. Das, S. V. Mudigunda, G. Darabdhara, P.K. Boruah, S. Ghar, A.K. Rengan*, M.R. Das*, Biocompatible functionalized AuPd bimetallic nanoparticles decorated on reduced graphene oxide sheets for photothermal therapy of targeted cancer cells, J. Photochem. Photobiol. B Biol. 212 (2020) 112028. 

  • A. Thomas, T. Appidi, A.B. Jogdand, S. Ghar, K. Subramaniyam, G. Prabusankar, J.R. Mohanty, A.K. Rengan*, Facile Synthesis of Fluorescent Polymer Encapsulated Metal (PoeM) Nanoparticles for Imaging and Therapeutic Applications, ACS Appl. Polym. Mater. 2 (2020) 1388–1397. 

  • T. Appidi, D.B. Pemmaraju, R.A. Khan, S.B. Alvi, R. Srivastava, M. Pal, N. Khan*, A.K. Rengan*, Light-triggered selective ROS-dependent autophagy by bioactive nanoliposomes for efficient cancer theranostics, Nanoscale. 12 (2020) 2028–2039. 

  • A. Jogdand, S.B. Alvi, P.S. Rajalakshmi, A.K. Rengan*, NIR-dye based mucoadhesive nanosystem for photothermal therapy in breast cancer cells, J. Photochem. Photobiol. B Biol. 208 (2020) 111901. 

  • S.B. Alvi, T. Appidi, B.P. Deepak, P.S. Rajalakshmi, G. Minhas, S.P. Singh, A. Begum, V. Bantal, R. Srivastava, N. Khan, A.K. Rengan*, The “nano to micro” transition of hydrophobic curcumin crystals leading to: In situ adjuvant depots for Au-liposome nanoparticle mediated enhanced photothermal therapy, Biomater. Sci. 7 (2019) 3866–3875. 

  • D. Pemmaraju, T. Appidi, G. Minhas, S.P. Singh, N. Khan, M. Pal, R. Srivastava*, A.K. Rengan*, Chlorophyll rich biomolecular fraction of A. cadamba loaded into polymeric nanosystem coupled with Photothermal Therapy: A synergistic approach for cancer theranostics, Int. J. Biol. Macromol. 110 (2018) 383–391. 

  • A.K. Rengan, A.B. Bukhari, A. Pradhan, R. Malhotra, R. Banerjee, R. Srivastava*, A. De, In Vivo Analysis of Biodegradable Liposome Gold Nanoparticles as Efficient Agents for Photothermal Therapy of Cancer, Nano Lett. 15 (2015) 842–848.

  • A.K. Rengan, M. Jagtap, A. De, R. Banerjee, R. Srivastava*, Multifunctional gold coated thermo-sensitive liposomes for multimodal imaging and photo-thermal therapy of breast cancer cells, Nanoscale. 6 (2014) 916–923. 

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Review Articles

  • S. Khatun, T. Appidi, A.K. Rengan*, The role played by bacterial infections in the onset and metastasis of cancer, Curr. Res. Microb. Sci. 2 (2021) 100078. 

  • S.P. Singh, T. Appidi, A.K. Rengan*, Biodegradable/disintegrable nanohybrids for photothermal theranostics, Proc. Indian Natl. Sci. Acad. 87 (2021) 94–106.

  • A. Hak, V. Ravasaheb Shinde, A.K. Rengan*, A review of advanced nanoformulations in phototherapy for cancer therapeutics, Photodiagnosis Photodyn. Ther. 33 (2021) 102205. 

  • A.M. Thanekar, S.A. Sankaranarayanan, A.K. Rengan*, Role of nano-sensitizers in radiation therapy of metastatic tumors, Cancer Treat. Res. Commun. 26 (2021) 100303. 

  • G. Ravichandran, A.K. Rengan*, Aptamer-mediated nanotheranostics for cancer treatment: A review, ACS Appl. Nano Mater. 3 (2020) 9542–9559. 

  • G. Darabdhara, M.R. Das*, S.P. Singh, A.K. Rengan*, S. Szunerits, R. Boukherroub, Ag and Au nanoparticles/reduced graphene oxide composite materials: Synthesis and application in diagnostics and therapeutics, Adv. Colloid Interface Sci. 271 (2019) 101991. 

  • P. Yadav, S.P. Singh, A.K. Rengan, A. Shanavas, R. Srivastava*, Gold laced bio-macromolecules for theranostic application, Int. J. Biol. Macromol. 110 (2018) 39–53.

Book Chapters

  • Sankaranarayanan S.A., Singh S.P., A.K. Rengan*. (2022) Theranostics: Principles, Materials, and Technical Advancements - BioSensing, Theranostics, and Medical Devices, Springer.

  • J.K.Gangasani, D.B.Pemmaraju, USN Murthy, A.K. Rengan, VGM Naidu* (2022) Chemistry of herbal biomolecules: Herbal Biomolecules in Healthcare Applications, Academic Press

  • D.B.Pemmaraju, A.Ghosh, J.K.Gangasani, USN Murthy, VGM Naidu, A.K.Rengan* (2022) Herbal biomolecules as nutraceuticals: Herbal Biomolecules in Healthcare Applications, Academic Press

  • SP Singh, AK Rengan* (2021) Microbial Interactions at Nanobiotechnology Interfaces: Molecular Mechanisms and Applications - Molecular Mechanisms Behind Nano‐Cancer Therapeutics, John Wiley & Sons, Inc.

  • S.P. Singh, A.K. Rengan* (2019) Nanomaterials for Antibiofilm Activity, Introd. to Biofilm Eng. Part 6 - Nanomater. Antibiofilm Act.

 

        * - Corresponding Author

Link to updated research articles

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Patents filed

​   Indian Patents

  • Plant derived fluorescent nanoparticles for treatment of cancer- IPA No 201941030649.

  • Ferroelectric polymer (β-pvdf) for control and mitigation of  Microbes under small voltage signals  - IPA No 202041050666.

  • Hybrid polymeric nanoformulation for the treatment and management of Retinoblastoma  IPA No 2141/CHE/2020

  • Fluorescent  Polymeric NPs as imaging probe- IPA No. 032865/CHE/2018

  • Liposomal nanoformulation for treatment of cancer IPA No. 35668 /CHE/2018 

  • A detection kit for the diagnosis of cervical cancer by quantification of visual inspection of acetic acid IPA No. 016604/CHE/2018.

  • Liponion as a multi-colour fluorescent biolabelling probe. IPA No. 2368/Mum/2015. (Granted)

  • Enzymatically degradable Lipos Au Nanoparticles for Cancer Theranostics  - IPA No. 4910/MUM/2015.

  • Photo-disintegrable metal nanoshells for multimodal imaging and passively targeted photothermal therapy of cancer                            IPA No. 4082/Mum/2015.(Granted)

  • Modified PEG-400 (mPEG-AA complex) and uses thereof. IPA No 4134/CHE/2021

  • Thermosensitive hydrogel for cancer therapeutics and methods preparation thereof - IPA No 23367/CHE/2020

  • Worldwide patent, PCT Application No. PCT/IN2016/000296 - Claiming priority from IPA no. 4910/MUM/2015. 

   US Patents

  • Modified PEG-400 (mPEG-AA complex) and uses thereof - USP No.: 17403964

  • Thermosensitive hydrogel for cancer therapeutics and methods preparation thereof - USP No.: 17325290

Funding Agencies

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