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At P-NAS lab we focus on novel ideas pertaining to the synthesis and use of various nanoparticles in healthcare. We believe in the ideology of multidisciplinary collaborations which enables us to integrate newer approaches. Nanotechnology has shown immense potential in tackling problems of modern medicine in recent times, but yet there remains many unanswered questions .........



Glutathione - IR 797 coupled Casein Nano-Trojan for augmenting the therapeutic efficacy of camptothecin in highly invasive triple-negative breast cancer, Biomaterials Advances (2024) 159,  Sajmina Khatun........A.K. Rengan*

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Selected Original Research Articles

  • Harsha Gopal Agrawal, Sajmina Khatun, Aravind Kumar Rengan, Ashutosh Kumar Mishra* , Tuning the Flavin Core via Donor Appendage for Selective Subcellular Bioimaging and PDT Application, Chemistry – A European Journal (2024)

  • Monika Pebam...............A.K. Rengan*, Self-assembled IR dye/Mitoxantrone loaded Porphysomes Nanosystem for Enhanced Combinatorial Chemo-Photothermal Cancer Therapy, Colloids and Surfaces B: Biointerfaces​ (2024)

  • Ankita Jaiswal, Monisha Patel, Anam Naseer, Simran Kumari, Neeraja Revi, Aravind Rengan, Alok Jain*, Aamir Nazir*, Nidhi Gour*, and Sandeep Verma* , Amyloid Mimicking Assemblies Formed by Glutamine, Glutamic Acid, and Aspartic Acid, ACS Chemical Neuroscience​ (2024)

  • Dheeraj Dehariya...............A.K. Rengan*, Hexagon Gold Nanoring-Mediated Combined Phototherapy for the Treatment of B16 Melanoma Cell Line, ACS Applied Nano Materials​ (2024)

  • Sri Amruthaa,...............A.K. Rengan*, Understanding the Role of NIR Laser Power and Wavelength in Tuning the Photothermal Transduction Efficiency of Gold Nanosystems in Biomedical Application, Indian Journal of Pure & Applied Physics (2024)

  • Paloma Patra...............A.K. Rengan*, Cancer cell membrane cloaked fluorescent liposomes loaded with metal-phenolic complex nanoparticles for combinatorial therapy against breast cancer, Applied Materials Today (2024)

  • Vinod R. Shinde, Ajinkya Madhukar Thanekar,...............A.K. Rengan*, Melanin-Ce6-loaded polydopamine nanoparticles-based enhanced phototherapy for B16 melanoma cancer cells, Nanotechnology (2024) 

  • S. Sagar, M. Pebam, R. Sinha, A.K. Rengan*, and T. K. Panda**, Magnesium-Catalyzed Dye-Embedded Polylactide Nanoparticles for the Effective Killing of Highly Metastatic B16F10 Melanoma Cells, ACS Omega (2024)

  • Tejaswini Appidi...............A.K. Rengan*, A lipo-polymeric hybrid nanosystem with metal enhanced fluorescence for targeted imaging of metastatic breast cancer, Nanotheranostics (2024) 

  • Sajmina Khatun...............A.K. Rengan*, 7-Amino-6H-anthra[9,1-cd] Isothiazol-6-one-Casein Nanosystem for Live Cell Staining and Augmenting Therapeutic Effectiveness in Triple Negative Breast Cancer, ACS Applied Nano Materials (2024) 

  • Sajmina Khatun...............A.K. Rengan*, Glutathione - IR 797 coupled Casein Nano-Trojan for augmenting the therapeutic efficacy of camptothecin in highly invasive triple-negative breast cancer, Biomaterials Advances (2024) 159

  • Mohammad Sadik Ali..............A.K. Rengan*, Accelerating Diabetic Wound Healing by Modulating the Inflammatory Environment using Quercetin-Rosemary Oil Lipid Nanoemulsions with Artificial Intelligence-based Wound Closure Analysis, Advanced Therapeutics  (2023) 034

  • Gayathri Ravichandran,...............A.K. Rengan*, The Multifaceted Role of Degradable Cobalt Nanoparticles: Dual-Target Starvation and Intracellular Acidification Engendering LC3-Associated Whole-Cell Autophagy, ACS Materials Letters 5 (2023) 2726

  • Sunil Venkanna Pogu, Dokkari Nagalaxmi Yadav, ...............A.K. Rengan* Copper iodide microhexagons: a potential therapeutic agent for surface microbial infection and melanoma Materials Advances 10 (2023) 1039

  • Dokkari Nagalaxmi Yadav, Sri Amruthaa, ...............A.K. Rengan* Bioinspired Gold coated Phage Nanosomes for Anti-Microbial and Anti-CancerTheranostics Materials Today Nano  23 (2023) 100348

  • Sushma Mudigunda, Sri Amruthaa,...........A.K. Rengan*, Ethosomal Nanoformulations for Combinational Photothermal Therapy of Fungal Keratitis Advanced Therapeutics 6 (2023)2200331 

  • S Khatun, M Pebam, CL Putta, A.K. Rengan*,  Camptothecin loaded Casein nanosystem for turning the therapeutic efficacy against highly metastatic triple-negative breast cancer cells, Biomaterials Science,11 (2023) 2518.

  • A Prajapati, A Srivastava, ...............A.K. Rengan*, High-Affinity DNA NAnomatrix: A platform technology for synergistics Drug Delivery and Photothermal Therapy, ACS Macro Letters 12 (2023) 255.

  • SV Mudigunda, DB Pemmaraju, SA Sankaranarayanan, A.K. Rengan*, Bioactive Polymeric Nanoparticles of Moringa oleifera Induced Phyto-Photothermal Sensitization for the Enhanced Therapy of Retinoblastoma, Pharmaceutics 2(2023), 15.

  • Vinod R. Shinde, S. Khatun, Ajinkya M. Thanekar, A. Hak, A.K. Rengan*, Lipid-Coated Red Fluorescent Carbon Dots for Imaging and Synergistic Phototherapy in Breast Cancer, Photodiagnosis and Photodynamic Therapy 41 (2023), 103314.

  • S.B.Alvi, P.S.Rajalakshmi, A.B.Jogdand, B.Nazia, V.Bantal, A.K.Rengan, Chitosan IR806 dye-based polyelectrolyte complex nanoparticles with mitoxantrone combination for effective chemo-photothermal therapy of metastatic triple-negative breast cancer, International Journal of Biological Macromolecules216, (2022),558.

  • Monika Pebam, Rajalakshmi P.S., Madhusree Gangopadhyay, Shashidhar Thatikonda, and Aravind Kumar Rengan*, Terminalia chebula Polyphenol and Near-Infrared Dye-Loaded Poly(lactic acid) Nanoparticles for Imaging and Photothermal Therapy of Cancer Cells , ACS Applied Bio Materials, 11,(2022) 5333.

  • Tejaswini Appidi, PS Rajalakshmi, Shubham A Chinchulkar, Arpan Pradhan, Hajera Begum, Veeresh Bantal, Rohit Srivastava, Ganesan Prabusankar, A.K.Rengan*, Plasmon-enhanced fluorescent gold coated novel lipo-polymeric hybrid nanosystem: Synthesis, characterization and application for imaging and photothermal therapy of breast cancer, Nanoscale 14 (2022) , 9112.

  • V.S.Mudigunda, D.Pemmaraju, S.Paradkar, E.R.Puppala,  B.Gawali, USN Murthy, VGM Naidu, A.K.Rengan*, Multifunctional polymeric nanoparticles for chemo/photo theranostics of retinoblastoma, ACS Biomat.Sci.Engg 8 (2022) 151–160.

  • Gangwar, Rahul, Karri Trinadha Rao, Sajmina Khatun, Aravind Kumar Rengan, Challapalli Subrahmanyam, and Siva Rama Krishna Vanjari. "Label-free miniaturized electrochemical nanobiosensor triaging platform for swift identification of the bacterial type." Analytica Chimica Acta  1233 (2022): 340482 .

  • S.B. Alvi, R. P S, N. Begum, A.B. Jogdand, B. Veeresh, A.K. Rengan*, In Situ Nanotransformable Hydrogel for Chemo-Photothermal Therapy of Localized Tumors and Targeted Therapy of Highly Metastatic Tumors, ACS Appl. Mater. Interfaces. (2021) 13,55862. 

  • Rajalakshmi P.S, S.B. Alvi, N. Begum, B. Veeresh, A.K. Rengan*, Self-Assembled Fluorosome-Polydopamine Complex for Efficient Tumor Targeting and Commingled Photodynamic/Photothermal Therapy of Triple-Negative Breast Cancer, Biomacromolecules. 22 (2021) 3926. 

  • S.B. Alvi, P.S. Rajalakshmi, A. Jogdand, A.Y. Sanjay, B. Veeresh, R. John, A.K. Rengan*, Iontophoresis mediated localized delivery of liposomal gold nanoparticles for photothermal and photodynamic therapy of acne, Biomater. Sci. 9 (2021) 1421.

  • D.V.S.K. Gunapu, Y.B. Prasad, V.S. Mudigunda, P. Yasam, A.K. Rengan, R. Korla, S.R.K. Vanjari, Development of robust, ultra-smooth, flexible and transparent regenerated silk composite films for bio-integrated electronic device applications, Int. J. Biol. Macromol. 176 (2021) 498. 

  • K.K. Gudimella, T. Appidi, H.F. Wu, V. Battula, A. Jogdand, A.K. Rengan*, G. Gedda*, Sand bath assisted green synthesis of carbon dots from citrus fruit peels for free radical scavenging and cell imaging, Colloids Surfaces B Biointerfaces. 197 (2021) 111362. 

  • P. Das, S. V. Mudigunda, G. Darabdhara, P.K. Boruah, S. Ghar, A.K. Rengan*, M.R. Das*, Biocompatible functionalized AuPd bimetallic nanoparticles decorated on reduced graphene oxide sheets for photothermal therapy of targeted cancer cells, J. Photochem. Photobiol. B Biol. 212 (2020) 112028. 

  • A. Thomas, T. Appidi, A.B. Jogdand, S. Ghar, K. Subramaniyam, G. Prabusankar, J.R. Mohanty, A.K. Rengan*, Facile Synthesis of Fluorescent Polymer Encapsulated Metal (PoeM) Nanoparticles for Imaging and Therapeutic Applications, ACS Appl. Polym. Mater. 2 (2020) 1388. 

  • T. Appidi, D.B. Pemmaraju, R.A. Khan, S.B. Alvi, R. Srivastava, M. Pal, N. Khan*, A.K. Rengan*, Light-triggered selective ROS-dependent autophagy by bioactive nanoliposomes for efficient cancer theranostics, Nanoscale. 12(2020) 2028. 

  • A. Jogdand, S.B. Alvi, P.S. Rajalakshmi, A.K. Rengan*, NIR-dye based mucoadhesive nanosystem for photothermal therapy in breast cancer cells, J. Photochem. Photobiol. B Biol. 208 (2020) 111901. 

  • S.B. Alvi, T. Appidi, B.P. Deepak, P.S. Rajalakshmi, G. Minhas, S.P. Singh, A. Begum, V. Bantal, R. Srivastava, N. Khan, A.K. Rengan*, The “nano to micro” transition of hydrophobic curcumin crystals leading to: In situ adjuvant depots for Au-liposome nanoparticle mediated enhanced photothermal therapy, Biomater. Sci. 7 (2019) 3866. 

  • D. Pemmaraju, T. Appidi, G. Minhas, S.P. Singh, N. Khan, M. Pal, R. Srivastava*, A.K. Rengan*, Chlorophyll rich biomolecular fraction of A. cadamba loaded into polymeric nanosystem coupled with Photothermal Therapy: A synergistic approach for cancer theranostics, Int. J. Biol. Macromol. 110 (2018) 383. 

  • A.K. Rengan, A.B. Bukhari, A. Pradhan, R. Malhotra, R. Banerjee, R. Srivastava*, A. De, In Vivo Analysis of Biodegradable Liposome Gold Nanoparticles as Efficient Agents for Photothermal Therapy of Cancer, Nano Lett. 15 (2015) 842.

  • A.K. Rengan, M. Jagtap, A. De, R. Banerjee, R. Srivastava*, Multifunctional gold coated thermo-sensitive liposomes for multimodal imaging and photo-thermal therapy of breast cancer cells, Nanoscale. 6 (2014) 916.

Review Articles

  • Aditya Srivastava, Meet Joshi, A K Rengan* Feeding the future: the role of nanotechnology in tailored nutrition, The Nucleus (2024)

  • Pramit Kumar Ghosh.......A K Rengan*, Telomerase: a nexus between cancer nanotherapy and circadian rhythm, Biomaterials Science (2024)

  • Sunjeet Saha.......A K Rengan*, Polyurethane Nanoparticles as Versatile Tools in Nanomedicine: A Review, ACS Applied Nano Materials (2024)

  • Hima Sree Buddhiraju.........A K Rengan* Advances in Peptide-Decorated Targeted Drug Delivery: Exploring Therapeutic Potential and Nanocarrier Strategies, ACS Applied Bio Materials (2023) 

  • Nitisha Beniwal..........A K Rengan*, Recent Trends in Bio-nanomaterials and Non-invasive Combinatorial Approaches of Photothermal Therapy against Cancer, Nanotheranostics (2024) 8(2)

  • Pavani Chowdary, Ananya Padmakumar, A K Rengan Exploring the potential of transethosomes in therapeutic delivery: A comprehensive review MedComm – Biomaterials and Applications 4 (2023) e59

  • Chandra Lekha Putta .......A. K. Rengan* Melatonin: Avenues in cancer therapy and its nanotechnological advancements MedComm – Biomaterials and Applications 2 (2023) e58

  • Monika Pebam....... A. K. Rengan* Nano Phyto-Phenols as potential immunomodulators: A review  Food and Humanity 1(2023) 809

  • Rounik Karmakar....... A. K. Rengan* Attributes of Nanomaterials and Nanotopographies for Improved Bone Tissue Engineering and Regeneration  ACS Applied Bio Materials (2023) 

  • Ananya Padmakumar, ........, A. K. Rengan* Bacteria-Premised Nanobiopesticides for the Management of Phytopathogens and Pests ACS Agric. Sci. Technol.10(2023)1021

  • Sadik Ali Mohammad, Arshadul Hak,.......A. K. Rengan* Radiotherapy, photodynamic therapy, and cryoablation‐induced abscopal effect: Challenges and future prospects Cancer Innovation 10(2023)1002

  • Sunil Venkanna Pogu, Dheeraj Dehariya,..........A. K. Rengan* A review on fabrication, actuation, and application of magnetic force driven, light-driven and DNA nano/microrobots in modern theranostics Molecular System Design and Engineering  4 (2023) 2546

  • Dheeraj Dehariya, Kalyani Eswar,..............., A. K. Rengan*Recent Advances of Nanobubble-based systems in Cancer Therapeutics: A Review Biomedical Engineering Advances 5 (2023)  100080

  • K Eswar, S Mukherjee, ......, A.K. Rengan*, Immunomodulatory Natural Polysaccharides: An Overview of the Mechanisms Involved - European Polymer Journal, 188 (2023) 111935.

  • S Khatun, CL Putta, A Hak, A. K. Rengan*, Immunomodulatory nanosystems: An emerging strategy to combact viral infections, Biomaterials, and Biosystems, 9 (2023) 100073.

  • A. Hak, M.S. Ali, S.A. Sankarnarayana, Vinod R. Shinde, A. K. Rengan*, Chlorine e6: A Promising Photosensitizer in Photo-Based  Cancer Nanomedicine, ACS Applied Bio Materials 6 (2023) 349.

  • Sajmina Khatun, Tejaswini Appidi,A. K. Rengan* Casein nanoformulations - Potential biomaterials in Food Bioscience (2022)

  • SA Chinchulkar, P Patra, D Dehariya, A Yu, AK Rengan, Polydopamine nanocomposites and their biomedical applications: A review, Polymers for Advanced Technologies, 10. (2022)5863.

  • DN Yadav, MS Ali, AM Thanekar, SV Pogu… A.K.Rengan*, Recent advancements in the design of nanodelivery systems of siRNA for cancer therapy, Mol. Pharmaceutics 19 (2022) 4506.

  • Pratyusha Sambangi, Subramaniam Gopalakrishnan, Monika Pebam , A.K.Rengan* , Nano-biofertilizers on soil health, chemistry, and microbial community: benefits and risks, Proceedings of the Indian National Science Academy volume 88, pages 357–368 (2022)

  • NP Koyande, R Srivastava, A Padmakumar, AK Rengan, Advances in Nanotechnology for Cancer Immunoprevention and Immunotherapy: A Review, Vaccines 10 (2022)1727.

  • P Patra, AK Rengan, Cancer Cell Membrane Cloaked Nanocarriers: A Biomimetic Approach Towards Cancer Theranostics, Materials Today Communications, 10 (2022) ​4289

  • A. Padmakumar, N. P. Koyande, & A. K. Rengan*, Role of hitchhiking on cancer therapeutics, Advanced Therapeutics 12 (2022) 42.

  • N. Koyande, M. Gangopadhyay, S. Thatikonda, A. K. Rengan*, The role of gut microbiota in the development of colorectal cancer: a review, International Journal of Colorectal Disease (2022) 37, 1509.

  • S. Khatun, T. Appidi, A.K. Rengan*, The role played by bacterial infections in the onset and metastasis of cancer, Curr. Res. Microb. Sci. 2 (2021) 100078. 

  • S.P. Singh, T. Appidi, A.K. Rengan*, Biodegradable/disintegrable nanohybrids for photothermal theranostics, Proc. Indian Natl. Sci. Acad. 87 (2021) 94.

  • A. Hak, V. Ravasaheb Shinde, A.K. Rengan*, A review of advanced nanoformulations in phototherapy for cancer therapeutics, Photodiagnosis Photodyn. Ther. 33 (2021) 102205. 

  • A.M. Thanekar, S.A. Sankaranarayanan, A.K. Rengan*, Role of nano-sensitizers in radiation therapy of metastatic tumors, Cancer Treat. Res. Commun. 26 (2021) 100303. 

  • G. Ravichandran, A.K. Rengan*, Aptamer-mediated nanotheranostics for cancer treatment: A review, ACS Appl. Nano Mater. 3 (2020) 9542 

  • G. Darabdhara, M.R. Das*, S.P. Singh, A.K. Rengan*, S. Szunerits, R. Boukherroub, Ag and Au nanoparticles/reduced graphene oxide composite materials: Synthesis and application in diagnostics and therapeutics, Adv. Colloid Interface Sci. 271 (2019) 101991. 

  • P. Yadav, S.P. Singh, A.K. Rengan, A. Shanavas, R. Srivastava*, Gold laced bio-macromolecules for theranostic application, Int. J. Biol. Macromol. 110 (2018) 39.

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Book Chapters

  • Rupali Srivastava............A.K. Rengan* (2024), Phytonanotechnologies for Addressing Antimicrobial Resistance, Medicinal Plants and Antimicrobial Therapies Springer

  • Sivasubramanian Murugappan............. A.K. Rengan* (2024), Drug-delivery, Antimicrobial, Anticancerous Applications of Green Synthesized Nanomaterials, Green Synthesis of Nanomaterials: Biological and Environmental Applications Wiley

  • Anindita Tarafdar..........A.K. Rengan* (2023) X-ray photoelectron spectroscopy for biomedical applications Analytical Techniques for Biomedical Nanotechnology  IOP Publishing

  • Aditya Srivastava..........A.K. Rengan* (2023) The Evolution of 3D Graphene and Its Derivatives for Theranostic Applications 3D Graphene Springer

  • Sabeerabi Bonala.......A.K. Rengan* (2023) Nanovectors for theranostic applications Advanced Nanoformulations Academic press

  • Sankaranarayanan SA........A.K. Rengan* (2023) Albumin-based nanocarriers for therapeutic applications Polymeric Nanosystems  Academic press

  • Shubham Arunrao Chinchulkar.......A.K. Rengan* (2023) 22 - Gold nanoparticle-based biosensing applications and fundamentals of sensor technology: principles and novel designs Fundamentals of Sensor Technology Elsevier

  • Shubham A. Chinchulkar, Sankaranarayanan S.A., A.K. Rengan* (2023) Nanobiosensor: Advancement in Disease Diagnostic, Springer.

  • T. Appidi, S. Mudigunda, A.K. Rengan* (2022) Cellulose Nanocrystals, Springer.

  • T. Appidi, S. Mudigunda, A.K. Rengan* (2022) Multi-Organs-on-a-Chip in Disease Modelling, Springer.

  • Sankaranarayanan S.A., Singh S.P., A.K. Rengan*. (2022) Theranostics: Principles, Materials, and Technical Advancements - BioSensing, Theranostics, and Medical Devices, Springer.

  • J.K.Gangasani, D.B.Pemmaraju, USN Murthy, A.K. Rengan, VGM Naidu* (2022) Chemistry of herbal biomolecules: Herbal Biomolecules in Healthcare Applications, Academic Press

  • D.B.Pemmaraju, A.Ghosh, J.K.Gangasani, USN Murthy, VGM Naidu, A.K.Rengan* (2022) Herbal biomolecules as nutraceuticals: Herbal Biomolecules in Healthcare Applications, Academic Press

  • SP Singh, AK Rengan* (2021) Microbial Interactions at Nanobiotechnology Interfaces: Molecular Mechanisms and Applications - Molecular Mechanisms Behind Nano‐Cancer Therapeutics, John Wiley & Sons, Inc.

  • S.P. Singh, .........A.K. Rengan* (2019) Nanomaterials for Antibiofilm Activity, Introd. to Biofilm Eng. Part 6 - Nanomater. Antibiofilm Act.

Link to updated research articles


Funding Agencies

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