Research

At P-NAS lab we focus on novel ideas pertaining to the synthesis and use of various nanoparticles in healthcare.We belief in the ideology of multidisciplinary collaborations which enables us to integrate newer approaches. Nanotechnology has shown immense potential in tackling problems of modern medicine in recent times, but yet there remains many unanswered questions .........

Our collaborations:

IIT- Bombay.
ACTREC-TMC -Mumbai.
CSIR -CCMB.
NIPER- Hyderabad.
LV Prasad Eye Institute.
University of Mumbai.
Hyderabad Central Univeristy.

Projects

The Lab is well funded with Projects from MHRD, DST, ICMR and DBT.

Publications

Link to updated research articles :

Selected Original Research Articles.....

Thomas A, Appidi T, Jogdand AB, Ghar S, Subramaniyam K, Prabusankar G, Jyoti M, Rengan AK. Facile Synthesis of Fluorescent Polymer Encapsulated Metal (PoeM) Nanoparticles for Imaging and Therapeutic Applications. ACS Appl Polym Mater 2020;2:1388–97.
Tejaswini Appidi, Deepak Bharadwaj Pemmaraju, Rafiq Ahmad Khan, Syed Baseeruddin Alvi, Rohit Srivastava, Mahadeb Pal, Nooruddin Khan, Rengan AK. Light-triggered selective ROS-dependent autophagy by bioactive nanoliposomes for efficient cancer theranostics. Nanoscale, 2020,12, 2028-2039.
Jogdand A, Alvi SB, Rajalakshmi PS, Rengan AK. NIR-dye based mucoadhesive nanosystem for photothermal therapy in breast cancer cells. J Photochem Photobiol B Biol 2020;208:111901.
Alvi SB, Appidi T, Deepak BP, Rajalakshmi PS, Minhas G, Singh SP, Begum A, Bantal V, Srivastava R, Khan N, Rengan AK. The "nano to micro" transition of hydrophobic curcumin crystals leading to in situ adjuvant depots for Au-liposome nanoparticle mediated enhanced photothermal therapy. Biomater Sci., 2019,7,3866-3875
Deepak S Chauhan, Amirali B Bukhari, Gayathri Ravichandran, Ramkrishn Gupta, Liya George, Radhika Poojari, Aravind Ingle, A K Rengan, Asifkhan Shanavas, Rohit Srivastava, Abhijit De. Enhanced EPR directed and Imaging guided Photothermal Therapy using Vitamin E Modified Toco-Photoxil. Nature – Scientific Reports 2018: 8:16673
Singh SP*, Alvi SB*, Pemmaraju D, Singh AD, Manda SV, Srivastava R@, Rengan AK. NIR triggered liposome gold nanoparticles entrapping curcumin as in situ adjuvant for photothermal treatment of skin cancer. Int J Biol Macromol 110 (2018): 375-382.
Pemmaraju D*, Appidi T*, Minhas G, Singh SP, Khan N, Pal M, Srivastava R@, Rengan AK@. Chlorophyll rich biomolecular fraction of A. cadamba loaded into polymeric nanosystem coupled with Photothermal Therapy: A synergistic approach for cancer theranostics. Int J Biol Macromol 110(2018), 383-391.(Impact Factor : 4.784, * Equal Contribution, @ Corresponding Author, No of citation:2)
Rengan AK*, Shanavas A*, Chauhan D, George L, Vats M, Samra NK, et al. Glycol Chitosan assisted in situ Reduction of Gold on Polymeric Template for Anti-cancer Theranostics. Int J Biol Macromol 110 (2018): 392-398.
Rengan AK*, Bukhari AB*, Pradhan A, Malhotra R, Banerjee R, Srivastava R, et al. In Vivo Analysis of Biodegradable Liposome Gold Nanoparticles as Efficient Agents for Photothermal Therapy of Cancer. NANO LETTERS 2015, 15, 842-48. (Impact Factor: 12.279, No of Citations: 180)
Rengan AK, Jagtap M, De A, Banerjee R, Srivastava R. Multifunctional gold coated thermo-sensitive liposomes for multimodal imaging and photo-thermal therapy of breast cancer cells. NANOSCALE, 2014;6:916–23.
Rengan AK*, Byagiri K*, Shanavas* A, Kundu GC, Srivastava R. Biocompatible Amphiphilic Pentablock Copolymeric Nanoparticles for Anti-Cancer Drug Delivery. J Biomed Nanotechnol 2014;10:1–11.
Rengan AK, Kundu G, Banerjee R, Srivastava R. Gold Nanocages as Effective Photothermal Transducers in Killing Highly Tumorigenic Cancer Cells. Particle 2014;31:398–405.

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Review Articles.....

Gitashree Darabdhara, Manash R. Das, Surya P. Singh, Aravind K. Rengan, Sabine Szunerits, Rabah Boukherroub,Ag and Au nanoparticles/reduced graphene oxide composite materials: Synthesis and application in diagnostics and therapeutics, Advances in Colloid and Interface Science, Volume 271, 2019, 101991, ISSN 0001-8686, (Impact factor: 8.243)
Yadav P, Singh SP, Rengan AK, Shanavas A, Srivastava R. Gold laced bio-macromolecules for theranostic application. Int J Biol Macromol. 2018 Apr 15;110:39-53. doi: 10.1016/j.ijbiomac.2017.10.124. Epub 2017 Oct 19. Review. PubMed PMID: 29056467.(Impact factor: 4.784, No of citation:4)
Yadav P*, Singh SP*, Rengan AK@, Shanavas A@, Srivastava R@. Gold laced bio-macromolecules for theranostic application. Int J Biol Macromol 2017. (Impact Factor : 3.67, * Equal Contribution, @ Corresponding Author)

Conferences.....

Sushma Mudigunda, Deepak P.V.P., A.Tejaswini, S.B. Alvi, Anil J. S.P. Singh, A.K. Rengan, Nanoformulation of Alkaloids from Moringa oleifera in combination with Photothermal effect for cancer theranostics, 7th International Translational Cancer Research Conference, 8- 11 February 2018, Chennai, India.
Appidi Tejaswini, S.B. Alvi, Deepak Pemmaraju, S.P. Singh, Afreen B, Veeresh B, Rohit Srivastava, Aravind Kumar Rengan. Photothermally Active Biomolecular Nanocarriers For Enhanced Skin Cancer Theranostics, NANOBIOTECK, 2nd Annual Conference, 6-8 December 2017, Trivandrum, Kerala, India.
Deepak Pemmaraju, Tejaswini Appidi, SB Alvi, SP Singh, Anil J, Sushma M, Rama S, Aravind Kumar Rengan., Engineered biomolecular nanoparticles for enhanced cancer theranostics. Special theme, Andhra Pradesh Academy of Sciences, 7-9th November 2017, Andhra University campus, Vishakapatnam, Andhra Pradesh, India.
S.B. Alvi, S.P. Singh, Deepak P.V.P., A.Tejaswini, Anil J., Sushma ., Anula D.S, Sasidhar V.M, Afreen B., Veeresh B., A.K. Rengan. Hybrid Gold Nanoparticles For The Treatment Of Melanoma By Photothermal therapy. 6th Asian Biomaterials Congress (ABMC 6) October 25‐27, 2017, Trivandrum, Kerala, India.
Rengan AK*, Byagiri K*, Shanavas* A, Kundu GC, Srivastava R. Biocompatible Amphiphilic Pentablock Copolymeric Nanoparticles for Anti-Cancer Drug Delivery. J Biomed Nanotechnol 2014;10:1–11. (Impact Factor: 5.068, No of Citations: 16)
Rengan AK, Kundu G, Banerjee R, Srivastava R. Gold Nanocages as Effective Photothermal Transducers in Killing Highly Tumorigenic Cancer Cells. Particle 2014;31:398–405. (Impact Factor : 4.194, No of Citations: 8)
Rengan AK, Banerjee R, Rohit S. Thermosensitive Gold Liposome Hybrid Nanostructures for Photothermal Therapy of Cancer. IEEE NANO 2012;1:1–4. (* Equal contribution)

Patents

Thermosensitive hydrogel for cancer therapeutics and methods preparation thereof - IPA No 23367/CHE/2020

Hybrid polymeric nanoformulation for the treatment and management of Retinoblastoma IPA No 2141/CHE/2020

Fluorescent Polymeric NPs as imaging probe- IPA No. 032865/CHE/2018

Liposomal nanoformulation for treatment of cancer IPA No. 35668 /CHE/2018

A detection kit for the diagnosis of cervical cancer by quantification of visual inspection of acetic acid IPA No. 016604/CHE/2018.

Liponion as a multi-colour fluorescent biolabelling probe. IPA No. 2368/Mum/2015.

Enzymatically degradable Lipos Au Nanoparticles for Cancer Theranostics - IPA No. 4910/MUM/2015.

Photo-disintegrable metal nanoshells for multimodal imaging and passively targeted photothermal therapy of cancer IPA No. 4082/Mum/2015.

Worldwide patent, PCT Application No. PCT/IN2016/000296 - Claiming priority from IPA no. 4910/MUM/2015.